Selank Peptide Research: Tuftsin Analog, GABA and BDNF Studies

Selank peptide research starts with an unusual origin story. Most research peptides begin as fragments of a hormone or growth factor. Selank begins as a fragment of an antibody. It is a synthetic, stabilized analog of tuftsin — a naturally occurring immune peptide — engineered in Russia to survive long enough in biological systems to […]
Retatrutide Peptide Research: The Triple Agonist, TRIUMPH Trials and FDA Status

Retatrutide Peptide Research: The Triple Agonist, TRIUMPH Trials and FDA Status Retatrutide peptide research is where incretin science stopped adding one receptor at a time. Retatrutide (development code LY3437943, Eli Lilly) is a single synthetic peptide engineered to activate three metabolic receptors at once — GIP, GLP-1 and glucagon — and its Phase 2 and […]
Sermorelin Peptide Research: GHRH(1-29), GH Pulses and FDA History

Sermorelin Peptide Research: GHRH(1-29), GH Pulses and FDA History Sermorelin peptide research occupies an unusual place in the peptide literature: this is one of the few research peptides that was once an FDA-approved prescription product. Sermorelin is a synthetic 29-amino-acid analogue of growth hormone-releasing hormone — GHRH(1-29) — the shortest fragment of the natural 44-amino-acid […]
Tirzepatide Peptide Research: Dual GIP/GLP-1 Mechanism, Trials and FDA Status

Tirzepatide peptide research is built around a question the incretin field argued about for two decades: what happens if one molecule activates both incretin receptors at once? Tirzepatide is a synthetic 39-amino-acid peptide engineered to agonize the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor simultaneously — the first dual agonist of […]
AOD-9604 Peptide Research: What the hGH Fragment Trials Actually Found

AOD-9604 peptide research starts with a clean engineering idea: can you keep only the fat-mobilizing tail of human growth hormone and leave the rest of the hormone behind? AOD-9604 is a synthetic 16-amino-acid fragment modeled on the C-terminal end of human growth hormone (hGH), developed in Australia in the 1990s as an anti-obesity drug candidate. […]
Epithalon Peptide Research: Telomerase and Telomere Studies

Epithalon peptide research is built around a fundamental question in cell biology: what happens when the protective caps on a cell’s chromosomes wear down? Epithalon — also spelled Epitalon — is a synthetic tetrapeptide of just four amino acids (Ala-Glu-Asp-Gly, abbreviated AEDG) reported in cell culture to switch telomerase back on in human somatic cells […]
Thymosin Alpha-1 Peptide Research: The Thymic Peptide, TLR Signaling and What the Big Trials Found

Thymosin alpha-1 peptide research occupies unusual ground in the peptide world. Most research peptides have cell data, animal data, and not much else. Thymosin alpha-1 (Tα1) has all of that plus something rare: decades of human clinical trials, a licensed pharmaceutical version sold in dozens of countries, a Phase 3 sepsis trial of more than […]
KPV Peptide Research: The α-MSH Tripeptide, PepT1 and NF-κB Studies

KPV peptide research starts with a deceptively simple question: how much of a hormone’s activity can survive in just three amino acids? KPV is the tripeptide lysine-proline-valine — the final three residues of alpha-melanocyte-stimulating hormone (α-MSH) — and in cell and animal models it retains a substantial share of its parent hormone’s anti-inflammatory signaling, without […]
Peptide Freeze-Thaw Cycles: What Repeated Freezing Does to Research Peptides

Peptide freeze thaw cycles sound harmless — freeze a solution, thaw it, use it — yet they are one of the most common and least visible ways researchers degrade their own material before an experiment even starts. A vial can look identical after five cycles while its contents have quietly aggregated, oxidized, or shifted in […]
Semaglutide Peptide Research: GLP-1 Mechanism, Trials and FDA Status

Semaglutide Peptide Research: GLP-1 Mechanism, Trials and FDA Status Semaglutide peptide research is unusual in the peptide field because, unlike most research compounds, semaglutide has completed large Phase 3 programs and holds FDA approvals in separate prescription drug products. That history makes it a useful reference compound for laboratory work on GLP-1 receptor signaling, metabolic […]